Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.
نویسندگان
چکیده
Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 49 4 شماره
صفحات -
تاریخ انتشار 2005